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KMID : 0895820020120020006
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Journal of Oriental Rehabilitation Medicine
2002 Volume.12 No. 2 p.6 ~ p.0
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Effects of Cortex Acanthopanacis Senticosi on the Collagen-Induced Arthritis in Lewis Rats
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Park Won-Tae
Kim Soon-Joong
Seo Il-Bok
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Abstract
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Objective: The purpose of this study is to find out the effects of Cortex Acanthopanacis Senticosi on the collagen-induced arthritis in the lewis rats. and we infere the effects of Cortex Acanthopanacis Senticosi on the rheumatoid arthritis in the human body.
Methods: We have investigated the lewis rats which had the collagen-induced arthritis as the experimental group and as the control group as well, but the normal group hadn`t been treated. we feed Cortex Acanthopanacis Senticosi only to an experimental group. And then effect on the body weight, paw edema volume, thickness of tarsal joint, the volume of TNF-α, IL-1β, and histopathological changes of tibiotarsal joints in the lewis rats were measured.
Results and Conclusions:
1. The paw edema volume of an experimental group were lower than the control group with statistically significant at 15days after treatment(P-value<0.05).
2. The tarsal joint of an experimental group were lower than the control group with statistically significant at 10days after treatment(P-value<0.05).
3. The volume of TNF-α at an experimental group were lower than the control group with statistically significant at 15days after treatment(P-value<0.001).
4. The volume of IL-1β at an experimental group were lower than control group with statistically significant at 15days after treatment(P-value<0.001).
5. An experimental group and a control group were showed ankylosing osteoarthritis, but an experimental group compared with the control group, alleviated in the fibrous ankylosis, destruction of articular cartilage and destruction of subchondral bony tissue.
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KEYWORD
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Cortex Acanthopanacis Senticosi, collagen-induced arthritis, TNF-α, IL-1β
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